Officers and Board Members
Dharma Singh Khalsa, M.D.
Randal Brooks, LPC, LISAC, CEAP
Treasurer - Carolyn
S. Sechler, CPA
Secretary - Kirti K.
Member - Carolyn
Comm unications Director
Russell Public Communications
Scientific Advisory Council
Ma Gloria Borras-Boneu, M.D.
GRD Health Institute
- Barcelona, Spain
Anu Kaur, MS, RD.
Registered Dietitian & Wellness/Health Coach
- Washington, DC
Sat Bir Singh Khalsa, Ph.D.
Assistant Professor of Medicine
Harvard Medical School
Brigham and Women's Hospital
- Boston, MA
Laura Jean Kokoska, R.N.
DNA Yoga Studio
- Old Lyme, CT
Helen Lavretsky, M.D., M.S.
Professor, Department of Psychiatry
UCLA Semel Institute and
Resnick Neuropsychiatric Hospital
- Los Angeles, CA
Andrew B. Newberg, M.D.
Assistant Professor, Radiology and Psychiatry
University of Pennsylvania
- Philadelphia, PA
George Perry, Ph.D.
Dean and Professor College of Sciences University
of Texas at San Antonio
- San Antonio, TX
Michelle Sierpina, Ph.D.
Founding Director UTMB Osher Institute for
Lifelong Learning University of Texas Medical Branch
- Galveston, TX
Victor S. Sierpina, M.D.
Professor in Integrative Medicine Associate
Professor of Family Medicine University of Texas Medical Branch
- Galveston, TX
Mark A. Smith, Ph.D.
Professor of Pathology Case Western Reserve
- Cleveland, OH
Yaakov Stern, Ph.D.
Director, Cognitive Neuroscience Division Taub
Institute for the Study of Alzheimer's Disease and the Aging
Brain Professor of Clinical Neuropsychology Columbia University
College of Physicians and Surgeons
- New York, NY
ARPF Outreach Update
by Conni Ingallina, ARPF
most of you have followed the work of the Alzheimer's
Research and Prevention Foundation for awhile and are familiar
with our 4 Pillars of Alzheimer's Prevention™, which are;
1) Nutrition, 2) Stress Management, 3) Exercise, 4)
ever wanted to know more? We have created a
tool for those of you who are interested in MORE.
Introducing: "The ARPF Prevention
Toolkit". This Toolkit is chockfull of
information, from the Kirtan Kriya meditation, a cd with a
lecture by Dr. Dharma Singh Khalsa on the 4 Pillars of
Alzheimer's Prevention™, another cd with a conversation between
Dr. Mark Sager and Dr. Dharma Singh Khalsa, brochures, in-depth
articles on each of the 4 Pillars, information about our
research, recipes and more!
Toolkit came as a direct result of people wanting to know
more. Well, now you can - for only $49.95 plus
shipping. In a handy binder that you can keep on your
shelf, the Prevention Toolkit is something you can refer to often
and as we add things to it, we'll send them to you free of
would like to order one, use the coupon found inside this
newsletter to order, or e-mail us at email@example.com
OR go to the store on our website at www.alzheimersprevention.org.
Become more informed today with our new ARPF
As you can see, there is always something going on
at the ARPF. Don't hesitate to check out our website at www.alzheimersprevention.org or e-mail us at firstname.lastname@example.org.
We are always happy to hear from you!
The Alzheimer's Research and Prevention Foundation
(ARPF ) is dedicated to reducing the incidence of Alzheimer's
disease by conducting clinical research and providing educational
1st Quarter 2010
Sleep and Cognitive Function
As Americans, our life expectancy has sky rocketed
from around age 40 in 1900, to an average age of 76 today. That's
over 30 years longer in only 100 years. And a baby born today has
the very real possibility of living to 100, and perhaps even
But for millions of people, the price of this
increased longevity has come with a horrible loss: their mind and
memory. Yes, that's correct. With added life, comes the very real
possibility of the development of Alzheimer's disease. Now I
recently read a posting on a blog that said: "50% of
Americans are doomed to get Alzheimer's." That is simply not
true. The statistics on the development of Alzheimer's are scary
enough; they don't have to be embellished. The reality is that,
unfortunately, if someone lives to age 85, as many more people
are now doing, then they have a 50% chance of developing this
horrible disease. But that's not everybody.
The greatest concern of people is that they are
losing their minds. They usually see small lapses of memory as a
sign of major decline. What I would like to discuss in this issue
is the importance of being aware of your lifestyle because, as
we've been discussing, it's the small things we do every day that
count. For example, are you aware that your sleep is a crucial
factor in your memory function?
One study that is funded by the National Institute
on Aging is examining how poor sleep quality is linked to poor
learning in older adults. Scientists believe that it's a
combination of sleep elements that contribute to the cognitive
decline that we experience as we grow old. Some of these elements
are interrupted sleep, processing and storing emotional memories,
and motor learning, which is boosted during a particular sleep
Another study in individuals with Alzheimer's
disease shows that those suffering from co-occurring depression
showed that sleep disturbances to be even more common.
Psychosocial interventions, such as sleep restriction, sleep
compression, multicomponent cognitive-behavioral therapy and
stimulus control were quite effective. Other promising
interventions included muscle relaxation and sleep hygiene
As we learn more about lifestyle impact on our
health and the development of memory loss and Alzheimer's
disease, we will continue to share this vital information with
you to support you in making positive lifestyle choices.
Dharma Singh Khalsa, M.D.
Dr. Perry joined the University of Texas San Antonio
faculty in 2006 from Case Western Reserve University here
he was Professor of Pathology and Neurosciences and Chair of the
Department of Pathology. He is also distinguished as one of the
top 20 Alzheimer's disease researchers with over 800
publications, one of the top 100 most-cited scientists in
www.in-cites.com/nobel/2007-neutop100.html Neuroscience &
Behavior and one of the top 25 scientists in Free Radical
research. He currently serves as and President for the American
Association of Neuropathologists. He is on the editorial board of
over 60 journals including American Journal of Pathology and
Journal of Biological Chemistry, and is Editor-in-Chief of
Journal of Alzheimer's Disease.
Our studies are focused on the mechanism of
formation and physiological consequences of the cytopathology of
Alzheimer disease. We have shown that oxidative damage is the
initial cytopathology in Alzheimer disease. We are working to
determine the sequence of events leading to neuronal oxidative
damage and the source of the increased oxygen radicals. Our
current studies focus on (i) the mechanism for RNA-based redox
metal binding; (ii) the consequences of RNA oxidation on protein
synthesis rate and fidelity; (iii) the role of redox active
metals in mediating prooxidant and antioxidant properties; (iv)
the signal transduction pathways altered in Alzheimer disease
that allow neurons to evade apoptosis; and (v) mechanism of
phosphorylation control of oxidative damage to neurofilament
FDA Approves Generic Aricept to Treat
Dementia Related to Alzheimer's Disease
According to a recent press release by the FDA,
the U.S. Food and Drug Administration approved the first generic
versions of Aricept (donepezil hydrochloride) orally
disintegrating tablets on Dec. 11, 2009 Donepezil hydrochloride
is indicated for the treatment of dementia related to Alzheimer's
Orally disintegrating tablets dissolve on the
tongue, without having to be swallowed whole. This may make it
easier to take the medication for older or disabled patients who
have difficulty swallowing.
"Generics offer greater access to health care
for all Americans," said Gary Buehler, director of the FDA's
Office of Generic Drugs. "Health care professionals and
consumers can be assured that FDA-approved generic drugs have met
the same rigorous standards as the brand-name drug and are the same as the branded in dosage form,
safety, strength, route of administration, quality, performance
characteristics and intended use."
Alzheimer's disease is an irreversible,
progressive brain disease that slowly destroys memory and
thinking skills and, eventually, the ability to carry out the
simplest tasks of daily living. In most people with Alzheimer's
disease, symptoms first appear after age 60. Alzheimer's disease
is the most common cause of dementia among older people, but it
is not a normal part of aging.
Dementia refers to a decline in cognitive function
that interferes with daily life and activities. Alzheimer's
disease starts in a region of the brain that affects recent
memory, then gradually spreads to other parts of the brain.
The generic donepezil hydrochloride orally
disintegrating tablets, manufactured by Mutual Pharmaceutical of
Philadelphia, have been approved in 5 milligram and 10 mg
For more information:
Consumer Education: Generic Drugs
'speed memory loss'
Infections outside the brain may speed memory
decline in Alzheimer's disease, UK researchers say.
In a study of 222 elderly people with
Alzheimer's they found that getting infections in places like the
chest or urinary tract could double memory loss.
The Southampton University researchers
think this leads to higher levels of an inflammatory protein
called tumour necrosis factor (TNF) in the blood.
They say better care to prevent infections
is very important.
The study published in the journal
Neurology followed the Alzheimer's patients for six months.
Between them 110 of the 222 subjects
developed a total of 150 infections, in areas such as the chest,
stomach and intestines and the urinary tract, which led to the production
of TNF proteins.
These are collectively known as acute
systemic inflammation events (SIEs).
"The worse the infection the worse the
effect on the memory"
Professor Clive Holmes, University of Southampton
Subjects with one or more SIEs during the
six months follow-up had two times the rate of cognitive decline
from their baseline score at the start of the study compared with
those who had no SIE.
And those patients who had high baseline
levels of TNF and then suffered an SIE over the following six
months had a 10 fold increase in the rate of cognitive decline
compared to those who were SIE free.
Professor Clive Holmes at the University of
Southampton, who led the research, said they had looked at
patients with mild, moderate and severe Alzheimer's disease.
"The worse the infection the worse the
effect on the memory, but this is only an association at the
"One might guess that people with a
more rapid rate of cognitive decline are more susceptible to
infections or injury, but we found no evidence to suggest that
people with more severe dementia were more likely to have
infections or injuries at the beginning of the study.
"It's important that older people,
people with dementia and carers treat any infection seriously and
seek medical help"
Dr Susanne Sorensen, Alzheimer's Society
"If further work proves that TNF is
causing more brain inflammation it may be possible to use drugs
that block TNF to help dementia sufferers."
Professor Holmes said although common
illnesses like colds and slight wounds could also set up an
inflammatory response in the body, the data from his study did
not support the idea that even these could cause memory loss.
Dr Susanne Sorensen, Head of Research,
Alzheimer's Society said: "This study is an important step
towards understanding the processes that occur during the onset
of Alzheimer's disease.
"We know there might be a link between
inflammatory processes and Alzheimer's but this is not yet fully
"These findings are helping us to
understand more about possible reasons for this link.
"In the meantime it's important that
older people, people with dementia and carers treat any infection
seriously and seek medical help. "
Rebecca Wood, Chief Executive of the
Alzheimer's Research Trust said: "This fascinating study
shows that infections and inflammation may be linked to memory
loss in Alzheimer's.
"We need to do more research into this
and all aspects of the disease to understand its causes."